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New chemical reactions take the lead in breaking the strongest bonds to form new intermediates

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  Takeaway: China chemical instrument network laboratory dynamic 】 【 a novel chemical reaction completely subvert the traditional first destroy the weakest in the chemical bonds, and the first strongest bonds "operation", and can form a new intermediate in chemical synthesis. This radical paradigm of chemical reaction proves that chemists can be pioneering the acquisition of compounds that conventional methods cannot. The paper was published in the journal of the American chemical society.

  Princeton university researchers choose catalyst system, through the synergy of two kinds of catalysts, first disconnect the protons (PCET) coupled electron transfer reactions in the strongest chemical bonds within the molecule: nitrogen, hydrogen bond (N - H). Many important biological systems, such as the photosynthetic system and respiratory system, use PCET to break strong chemical bonds. Since it is not known which catalysts are present in PCET, this principle has not been popularized in the synthesis of new molecules.

  Physicists network reported, the researchers chose a simple mathematical formula, this formula can help them accurately calculate any pair of catalyst synergism when disconnect the strongest bond strength, they named it "effective key value".

  The researchers tested the efficiency of the formula in the laboratory: there was a strong correlation between the effective bond strength and the reaction efficiency. When the effective bond strength value is higher or lower than that of the nitrogen-hydrogen bond strength value, the intermediate yield will be very low. When these two values are the same, very high intermediate yield is obtained.

  Lead author gilbert tsai has successfully found the amazing catalyst system and studied the mechanism of the catalyst. He found that the catalyst, dibutyl phosphate, was the first to initiate a chemical reaction. It could pull hydrogen atoms apart in the nitrogen-hydrogen bond, making the nitrogen-hydrogen bond longer and longer and weaker. Another catalyst, the metal iridium complex, targets weakened nitrogen-hydrogen bonds, "yanking" an electron from the electron pair of the bonds and cutting them off in the middle.

  When the nitrogen - hydrogen bond is broken off, the obtained nitrogen intermediates are very active, and can combine with carbon to form carbon-nitrogen bond, producing more complex chemical products. Without discovering the true nature of PCET catalysts, the new research provides a platform for the development of new chemical reactions and may even create greater value.

  Robert lawless, an associate professor of chemistry who led the study, said the idea would open up a whole new field of chemistry. Takeaway: China chemical instrument network laboratory dynamic 】 【 a novel chemical reaction completely subvert the traditional first destroy the weakest in the chemical bonds, and the first strongest bonds "operation", and can form a new intermediate in chemical synthesis. This radical paradigm of chemical reaction proves that chemists can be pioneering the acquisition of compounds that conventional methods cannot. The paper was published in the journal of the American chemical society.

  Princeton university researchers choose catalyst system, through the synergy of two kinds of catalysts, first disconnect the protons (PCET) coupled electron transfer reactions in the strongest chemical bonds within the molecule: nitrogen, hydrogen bond (N - H). Many important biological systems, such as the photosynthetic system and respiratory system, use PCET to break strong chemical bonds. Since it is not known which catalysts are present in PCET, this principle has not been popularized in the synthesis of new molecules.

  Physicists network reported, the researchers chose a simple mathematical formula, this formula can help them accurately calculate any pair of catalyst synergism when disconnect the strongest bond strength, they named it "effective key value".

  The researchers tested the efficiency of the formula in the laboratory: there was a strong correlation between the effective bond strength and the reaction efficiency. When the effective bond strength value is higher or lower than that of the nitrogen-hydrogen bond strength value, the intermediate yield will be very low. When these two values are the same, very high intermediate yield is obtained.

  Lead author gilbert tsai has successfully found the amazing catalyst system and studied the mechanism of the catalyst. He found that the catalyst, dibutyl phosphate, was the first to initiate a chemical reaction. It could pull hydrogen atoms apart in the nitrogen-hydrogen bond, making the nitrogen-hydrogen bond longer and longer and weaker. Another catalyst, the metal iridium complex, targets weakened nitrogen-hydrogen bonds, "yanking" an electron from the electron pair of the bonds and cutting them off in the middle.

  When the nitrogen - hydrogen bond is broken off, the obtained nitrogen intermediates are very active, and can combine with carbon to form carbon-nitrogen bond, producing more complex chemical products. Without discovering the true nature of PCET catalysts, the new research provides a platform for the development of new chemical reactions and may even create greater value.

  Robert lawless, an associate professor of chemistry who led the study, said the idea would open up a whole new field of chemistry.

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